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ResearchIn-Press PreviewCardiologyDevelopment Open Access | 10.1172/JCI169112
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by He, X. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Yang, T. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Lu, Y. in: JCI | PubMed | Google Scholar |
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Wu, G. in: JCI | PubMed | Google Scholar |
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Dai, G. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Ma, Q. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Zhang, M. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Zhou, H. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Long, T. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Yan, Y. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Liang, Z. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Liu, C. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Pu, W. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Dong, Y. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Ou, J. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Chen, H. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Mably, J. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by He, J. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Wang, D. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America
3NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China
4Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
5Center for Regenerative Medicine, USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, United States of America
Find articles by Huang, Z. in: JCI | PubMed | Google Scholar
Published May 14, 2024 - More info
One of the features of pathological cardiac hypertrophy is enhanced translation and protein synthesis. Translational inhibition has been shown to be an effective means of treating cardiac hypertrophy, although system-wide side effects are common. Regulators of translation, such as cardiac-specific long non-coding RNAs (lncRNAs), could provide new, more targeted, therapeutic approaches to inhibit cardiac hypertrophy. Therefore, we generated mice lacking a previously identified lncRNA named CARDINAL to examine its cardiac function. We demonstrate that CARDINAL is a cardiac-specific, ribosome associated lncRNA and show that its expression is induced in the heart upon pathological cardiac hypertrophy; its deletion in mice exacerbates stress-induced cardiac hypertrophy and augments protein translation. In contrast, overexpression of CARDINAL attenuates cardiac hypertrophy in vivo and in vitro, and suppresses hypertrophy-induced protein translation. Mechanistically, CARDINAL interacts with developmentally regulated GTP binding protein 1 (DRG1) and blocks its interaction with DRG family regulatory protein 1 (DFRP1); as a result, DRG1 is downregulated, thereby modulating the rate of protein translation in the heart in response to stress. This study provides evidence for the therapeutic potential of targeting cardiac-specific lncRNAs to suppress disease-induced translational changes and to treat cardiac hypertrophy and heart failure.