No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases
Background: Patients with paraneoplastic pemphigus (PNP) and inflammatory bowel
diseases, such as Crohn's disease (CD) and ulcerative colitis (UC), develop autoantibodies
against simple epithelial cells. About 20–30% of patients with PNP develop fatal
bronchiolitis obliterans, in which autoantibody-mediated injury is suspected because of in
vivo IgG deposition on cell surfaces of bronchial epithelia. Objective: The purpose of this
study is to determine whether patients with PNP, CD and UC have IgG autoantibodies …
diseases, such as Crohn's disease (CD) and ulcerative colitis (UC), develop autoantibodies
against simple epithelial cells. About 20–30% of patients with PNP develop fatal
bronchiolitis obliterans, in which autoantibody-mediated injury is suspected because of in
vivo IgG deposition on cell surfaces of bronchial epithelia. Objective: The purpose of this
study is to determine whether patients with PNP, CD and UC have IgG autoantibodies …
