Tuberculosis genes expressed during persistence and reactivation in the resistant rabbit model
AK Kesavan, M Brooks, JA Tufariello, J Chan… - Tuberculosis, 2009 - Elsevier
As previously published, after aerosol infection with Mycobacterium tuberculosis H37Rv,
New Zealand white rabbits established infection with active bacillary replication, but later
contained disease to a paucibacillary state through an effective adaptive response
consistent with latency. Despite the heterogeneity among outbred rabbits, the resistant
response was uniform. Immunosuppression resulted in reactivation with increased lung
bacillary burden. Using this rabbit model, we isolated bacillary RNA from infected rabbit …
New Zealand white rabbits established infection with active bacillary replication, but later
contained disease to a paucibacillary state through an effective adaptive response
consistent with latency. Despite the heterogeneity among outbred rabbits, the resistant
response was uniform. Immunosuppression resulted in reactivation with increased lung
bacillary burden. Using this rabbit model, we isolated bacillary RNA from infected rabbit …
