[HTML][HTML] Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of β-catenin
S Kishida, H Yamamoto, S Ikeda, M Kishida… - Journal of Biological …, 1998 - ASBMB
The regulators of G protein signaling (RGS) domain of Axin, a negative regulator of the Wnt
signaling pathway, made a complex with full-length adenomatous polyposis coli (APC) in
COS, 293, and L cells but not with truncated APC in SW480 or DLD-1 cells. The RGS
domain directly interacted with the region containing the 20-amino acid repeats but not with
that containing the 15-amino acid repeats of APC, although both regions are known to bind
to β-catenin. In the region containing seven 20-amino acid repeats, the region containing the …
signaling pathway, made a complex with full-length adenomatous polyposis coli (APC) in
COS, 293, and L cells but not with truncated APC in SW480 or DLD-1 cells. The RGS
domain directly interacted with the region containing the 20-amino acid repeats but not with
that containing the 15-amino acid repeats of APC, although both regions are known to bind
to β-catenin. In the region containing seven 20-amino acid repeats, the region containing the …
