SPARC gene expression is repressed in human urothelial cells (UROtsa) exposed to or malignantly transformed by cadmium or arsenite
SPARC belongs to a class of extracellular matrix-associated proteins that have
counteradhesive properties. The ability of SPARC to modulate cell–cell and cell–matrix
interactions provides a strong rationale for studies designed to determine its expression in
cancer. The objective of this study was to determine if SPARC expression was altered in
cadmium (Cd2+) and arsenite (As3+) induced bladder cancer and if these alterations were
present in archival specimens of human bladder cancer. The expression of SPARC was …
counteradhesive properties. The ability of SPARC to modulate cell–cell and cell–matrix
interactions provides a strong rationale for studies designed to determine its expression in
cancer. The objective of this study was to determine if SPARC expression was altered in
cadmium (Cd2+) and arsenite (As3+) induced bladder cancer and if these alterations were
present in archival specimens of human bladder cancer. The expression of SPARC was …