Secreted protein acidic and rich in cysteine as a regulator of murine ovarian cancer growth and chemosensitivity
SLB Phelps, J Carbon, A Miller, E Castro-Rivera… - American journal of …, 2009 - Elsevier
OBJECTIVE: Secreted protein acidic and rich in cysteine (SPARC) influences the growth of
several solid tumors. Our objectives were to determine the effect of SPARC on the growth
and response to cisplatin therapy of platinum-resistant ovarian cancer. STUDY DESIGN:
SPARC expression was determined in 4 platinum-resistant ovarian cancer cell lines. The
effect of increasing SPARC on cell proliferation was determined in vitro. The effect of host-
derived SPARC on tumor growth and response to therapy was determined in vivo using the …
several solid tumors. Our objectives were to determine the effect of SPARC on the growth
and response to cisplatin therapy of platinum-resistant ovarian cancer. STUDY DESIGN:
SPARC expression was determined in 4 platinum-resistant ovarian cancer cell lines. The
effect of increasing SPARC on cell proliferation was determined in vitro. The effect of host-
derived SPARC on tumor growth and response to therapy was determined in vivo using the …
