Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain
T Mizuochi, ST Yee, M Kasai, T Kakiuchi, D Muno… - Immunology letters, 1994 - Elsevier
The effect of highly selective inhibitors of cathepsins on the processing of ovalbumin (OVA)
and the presentation of an OVA-derived antigenic peptide (OVA 323–339) by antigen
presenting cells (APC) was investigated. Both CA-074 (a specific inhibitor of cathepsin B)
and pepstatin A (a specific inhibitor of cathepsin D) showed an inhibitory effect on the IL-2
production from an OVA-specific, IA d-restricted helper T (Th) cell clone upon stimulation
with OVA presented by the IA d-positive APC. In contrast, the presentation of the antigenic …
and the presentation of an OVA-derived antigenic peptide (OVA 323–339) by antigen
presenting cells (APC) was investigated. Both CA-074 (a specific inhibitor of cathepsin B)
and pepstatin A (a specific inhibitor of cathepsin D) showed an inhibitory effect on the IL-2
production from an OVA-specific, IA d-restricted helper T (Th) cell clone upon stimulation
with OVA presented by the IA d-positive APC. In contrast, the presentation of the antigenic …