[HTML][HTML] Functional embryonic cardiomyocytes after disruption of the L-type α1C (Cav 1.2) calcium channel gene in the mouse
C Seisenberger, V Specht, A Welling, J Platzer… - Journal of Biological …, 2000 - ASBMB
The L-type α 1C (Ca v 1.2) calcium channel is the major calcium entry pathway in cardiac
and smooth muscle. We inactivated theCa v 1.2 gene in two independent mouse lines that
had indistinguishable phenotypes. Homozygous knockout embryos (Ca v 1.2−/−) died
before day 14.5 postcoitum (pc). At day 12.5 pc, the embryonic heart contracted with
identical frequency in wild type (+/+), heterozygous (+/−), and homozygous (−/−) Ca v 1.2
embryos. Beating of isolated embryonic cardiomyocytes depended on extracellular calcium …
and smooth muscle. We inactivated theCa v 1.2 gene in two independent mouse lines that
had indistinguishable phenotypes. Homozygous knockout embryos (Ca v 1.2−/−) died
before day 14.5 postcoitum (pc). At day 12.5 pc, the embryonic heart contracted with
identical frequency in wild type (+/+), heterozygous (+/−), and homozygous (−/−) Ca v 1.2
embryos. Beating of isolated embryonic cardiomyocytes depended on extracellular calcium …