Role of T cells in the modulation of PTH action: physiological and clinical significance
R Pacifici - Endocrine, 2013 - Springer
Endocrine, 2013•Springer
Osteoimmunology is new field of research dedicated to the study of the interactions between
the immune system and bone. Among the cells of the immune system that regulate bone and
hemopoietic cells are T lymphocytes. These cells secrete osteoclastogenic cytokines such
as RANKL and TNF, as well as factors that stimulate bone formation and hemopoietic cells,
one of which is Wnt10b. This article will review the evidence that T cells are implicated in the
mechanism of action of parathyroid hormone (PTH) in bone and on the hemopoietic system.
the immune system and bone. Among the cells of the immune system that regulate bone and
hemopoietic cells are T lymphocytes. These cells secrete osteoclastogenic cytokines such
as RANKL and TNF, as well as factors that stimulate bone formation and hemopoietic cells,
one of which is Wnt10b. This article will review the evidence that T cells are implicated in the
mechanism of action of parathyroid hormone (PTH) in bone and on the hemopoietic system.
Abstract
Osteoimmunology is new field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate bone and hemopoietic cells are T lymphocytes. These cells secrete osteoclastogenic cytokines such as RANKL and TNF, as well as factors that stimulate bone formation and hemopoietic cells, one of which is Wnt10b. This article will review the evidence that T cells are implicated in the mechanism of action of parathyroid hormone (PTH) in bone and on the hemopoietic system.
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