[HTML][HTML] Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesis

Y Yasuda, S Masuda, M Chikuma, K Inoue… - Journal of Biological …, 1998 - ASBMB
Although erythropoietin (Epo) has been shown to possess in vitro angiogenic activity, its
physiological significance has not been demonstrated. Normally angiogenesis does not
occur actively in adults but an exception is the female reproductive organ. In the uterine
endometrium, angiogenesis takes place actively for supporting the endometrial growth that
occurs during transition from the diestrus to estrous stage. This transition is under control of
17β-estradiol (E 2), an ovarian hormone, and can be mimicked by injection of E 2 to …