[HTML][HTML] μ-Opioid receptor activates signaling pathways implicated in cell survival and translational control
RD Polakiewicz, SM Schieferl, AC Gingras… - Journal of Biological …, 1998 - ASBMB
The μ-opioid receptor mediates the analgesic and addictive properties of morphine. Despite
the clinical importance of this G-protein-coupled receptor and many years of
pharmacological research, few intracellular signaling mechanisms triggered by morphine
and other μ-opioid agonists have been described. We report that μ-opioid agonists stimulate
three different effectors of a phosphoinositide 3-kinase (PI3K)-dependent signaling cascade.
By using a cell line stably transfected with the μ-opioid receptor cDNA, we show that the …
the clinical importance of this G-protein-coupled receptor and many years of
pharmacological research, few intracellular signaling mechanisms triggered by morphine
and other μ-opioid agonists have been described. We report that μ-opioid agonists stimulate
three different effectors of a phosphoinositide 3-kinase (PI3K)-dependent signaling cascade.
By using a cell line stably transfected with the μ-opioid receptor cDNA, we show that the …