Mammalian target of rapamycin (mTOR) controls mRNA translation and is critical for
neuronal plasticity. However, how it participates in central sensitization underlying chronic
pain is unclear. Here, we show that NMDA receptors are required for the functional role of
spinal cord mTOR in bone cancer pain induced by injecting prostate cancer cells (PCCs)
into the tibia. Intrathecal rapamycin, a specific mTOR inhibitor, dose dependently attenuated
the development and maintenance of PCC-induced mechanical allodynia and thermal …