Catalytic inhibitors of DNA topoisomerase II
T Andoh, R Ishida - Biochimica et Biophysica Acta (BBA)-Gene Structure …, 1998 - Elsevier
Catalytic inhibitors of mammalian DNA topoisomerase II have been found recently in natural
and synthetic compounds. These compounds target the enzyme within the cell and inhibit
various genetic processes involving the enzyme, such as DNA replication and chromosome
dynamics, and thus proved to be good probes for the functional analyses of the enzyme in a
variety of eukaryotes from yeast to mammals. Catalytic inhibitors were shown to be
antagonists against topoisomerase II poisons. Thus bis (2, 6-dioxopiperazines) have a …
and synthetic compounds. These compounds target the enzyme within the cell and inhibit
various genetic processes involving the enzyme, such as DNA replication and chromosome
dynamics, and thus proved to be good probes for the functional analyses of the enzyme in a
variety of eukaryotes from yeast to mammals. Catalytic inhibitors were shown to be
antagonists against topoisomerase II poisons. Thus bis (2, 6-dioxopiperazines) have a …