[HTML][HTML] Facilitating Akt clearance via manipulation of Hsp70 activity and levels
Members of the 70-kDa heat shock family can control and manipulate a host of oncogenic
client proteins. This role of Hsp70 in both the folding and degradation of these client proteins
makes it a potential drug target for certain forms of cancer. The phenothiazine family of
compounds, as well as the flavonoid myricetin, was recently shown to inhibit Hsp70-ATPase
activity, whereas members of the dihydropyrimidine family stimulated ATPase function. Akt, a
major survival kinase, was found to be under the regulation of Hsp70, and when the ATPase …
client proteins. This role of Hsp70 in both the folding and degradation of these client proteins
makes it a potential drug target for certain forms of cancer. The phenothiazine family of
compounds, as well as the flavonoid myricetin, was recently shown to inhibit Hsp70-ATPase
activity, whereas members of the dihydropyrimidine family stimulated ATPase function. Akt, a
major survival kinase, was found to be under the regulation of Hsp70, and when the ATPase …