[HTML][HTML] Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40
E Oflazoglu, IJ Stone, L Brown, KA Gordon… - British journal of …, 2009 - nature.com
E Oflazoglu, IJ Stone, L Brown, KA Gordon, N Van Rooijen, M Jonas, CL Law, IS Grewal…
British journal of cancer, 2009•nature.comSGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma
activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show
antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute
significantly to the therapeutic activities and that the antitumour effects of SGN-40 depend on
Fc interactions.
activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show
antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute
significantly to the therapeutic activities and that the antitumour effects of SGN-40 depend on
Fc interactions.
Abstract
SGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute significantly to the therapeutic activities and that the antitumour effects of SGN-40 depend on Fc interactions.
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