[HTML][HTML] NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10
Y Yang, H Cimen, MJ Han, T Shi, JH Deng… - Journal of Biological …, 2010 - ASBMB
A member of the sirtuin family of NAD+-dependent deacetylases, SIRT3, is located in
mammalian mitochondria and is important for regulation of mitochondrial metabolism, cell
survival, and longevity. In this study, MRPL10 (mitochondrial ribosomal protein L10) was
identified as the major acetylated protein in the mitochondrial ribosome. Ribosome-
associated SIRT3 was found to be responsible for deacetylation of MRPL10 in an NAD+-
dependent manner. We mapped the acetylated Lys residues by tandem mass spectrometry …
mammalian mitochondria and is important for regulation of mitochondrial metabolism, cell
survival, and longevity. In this study, MRPL10 (mitochondrial ribosomal protein L10) was
identified as the major acetylated protein in the mitochondrial ribosome. Ribosome-
associated SIRT3 was found to be responsible for deacetylation of MRPL10 in an NAD+-
dependent manner. We mapped the acetylated Lys residues by tandem mass spectrometry …