Diffuse and focal nesidioblastosis: a clinicopathological study of 24 patients with persistent neonatal hyperinsulinemic hypoglycemia
A Goossens, W Gepts, JM Saudubray… - The American journal …, 1989 - journals.lww.com
The morphological abnormalities of the endocrine pancreas that underlie persistent
neonatal hyperinsulinemic hypoglycemia (PNHH) and are included under the heading
“nesidioblastosis” appear to be heterogeneous. We studied pancreatic specimens of 24
patients by light microscopy and immunocytochemistry in order to classify the changes of the
endocrine pancreas and relate them to the therapy applied. Two main forms of
nesidioblastosis were recognized: a focal and a diffuse type. Both types occurred with equal …
neonatal hyperinsulinemic hypoglycemia (PNHH) and are included under the heading
“nesidioblastosis” appear to be heterogeneous. We studied pancreatic specimens of 24
patients by light microscopy and immunocytochemistry in order to classify the changes of the
endocrine pancreas and relate them to the therapy applied. Two main forms of
nesidioblastosis were recognized: a focal and a diffuse type. Both types occurred with equal …