[HTML][HTML] Proplatelet formation in heterozygous Bernard‐Soulier syndrome type Bolzano
A Balduini, A Malara, A Pecci, S Badalucco… - Journal of Thrombosis …, 2009 - Elsevier
Summary Background: Although mutations of GPIbα are among the most frequent causes of
inherited platelet disorders, the mechanisms for the onset of thrombocytopenia and platelet
macrocytosis are still poorly defined. Objective: In this work we analyzed in vitro
megakaryocyte differentiation and proplatelet formation in six subjects heterozygous for the
Ala156Val mutation in the GPIbα (Bolzano mutation). Methods: Human megakaryocytes
were obtained by differentiation of patient cord blood‐derived CD34+ cells and peripheral …
inherited platelet disorders, the mechanisms for the onset of thrombocytopenia and platelet
macrocytosis are still poorly defined. Objective: In this work we analyzed in vitro
megakaryocyte differentiation and proplatelet formation in six subjects heterozygous for the
Ala156Val mutation in the GPIbα (Bolzano mutation). Methods: Human megakaryocytes
were obtained by differentiation of patient cord blood‐derived CD34+ cells and peripheral …