[HTML][HTML] Identification of an RNA binding specificity for the potential splicing factor TLS
A Lerga, M Hallier, L Delva, C Orvain, I Gallais… - Journal of Biological …, 2001 - ASBMB
The TLS/FUS gene is involved in a recurrent chromosomal translocation in human myxoid
liposarcomas. We previously reported that TLS is a potential splicing regulator able to
modulate the 5′-splice site selection in an E1A pre-mRNA. Using an in vitroselection
procedure, we investigated whether TLS exhibits a specificity with regard to RNA
recognition. The RNAs selected by TLS share a common GGUG motif. Mutation of a G or U
residue within this motif abolishes the interaction of TLS with the selected RNAs. We showed …
liposarcomas. We previously reported that TLS is a potential splicing regulator able to
modulate the 5′-splice site selection in an E1A pre-mRNA. Using an in vitroselection
procedure, we investigated whether TLS exhibits a specificity with regard to RNA
recognition. The RNAs selected by TLS share a common GGUG motif. Mutation of a G or U
residue within this motif abolishes the interaction of TLS with the selected RNAs. We showed …
