[HTML][HTML] Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model
X Xin, M Majumder, GV Girish, V Mohindra… - Laboratory …, 2012 - Elsevier
We reported that cyclo-oxygenase (COX)-2 expression in human breast cancer stimulated
cancer cell migration and invasiveness, production of vascular endothelial growth factor
(VEGF)-C and lymphangiogenesis in situ, largely from endogenous PGE2-mediated
stimulation of prostaglandin E (EP) 1 and EP4 receptors, presenting them as candidate
therapeutic targets against lymphatic metastasis. As human breast cancer xenografts in
immuno-compromised mice have limitations for preclinical testing, we developed a …
cancer cell migration and invasiveness, production of vascular endothelial growth factor
(VEGF)-C and lymphangiogenesis in situ, largely from endogenous PGE2-mediated
stimulation of prostaglandin E (EP) 1 and EP4 receptors, presenting them as candidate
therapeutic targets against lymphatic metastasis. As human breast cancer xenografts in
immuno-compromised mice have limitations for preclinical testing, we developed a …