A porcine model of familial adenomatous polyposis
T Flisikowska, C Merkl, M Landmann, S Eser, N Rezaei… - Gastroenterology, 2012 - Elsevier
T Flisikowska, C Merkl, M Landmann, S Eser, N Rezaei, X Cui, M Kurome, V Zakhartchenko…
Gastroenterology, 2012•ElsevierWe created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC)
gene (APC) that are orthologous to those responsible for human familial adenomatous
polyposis (FAP). One-year-old pigs with the APC1311 mutation (orthologous to human
APC1309) have aberrant crypt foci and low-and high-grade dysplastic adenomas in the
large intestine, similar to the precancerous lesions that develop in patients with FAP.
Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC. This large …
gene (APC) that are orthologous to those responsible for human familial adenomatous
polyposis (FAP). One-year-old pigs with the APC1311 mutation (orthologous to human
APC1309) have aberrant crypt foci and low-and high-grade dysplastic adenomas in the
large intestine, similar to the precancerous lesions that develop in patients with FAP.
Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC. This large …
We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC1311 mutation (orthologous to human APC1309) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC. This large-animal, genetic model of FAP will be useful in the development of diagnostics and therapeutics for colorectal cancer. DNA sequence data: NCBI accession number GU951771.
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