Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus

HP Hahn, PL Blount, K Ayub, KM Das… - The American journal …, 2009 - journals.lww.com
Barrett esophagus (BE) is defined by the presence of metaplastic esophageal columnar
epithelium with goblet cells within endoscopically recognizable areas of the esophagus.
However, some carcinomas in BE, or from the gastroesophageal junction region, develop
within mucosa devoid of goblet cells. However, the biologic properties, pathogenesis, and
risk of malignancy of metaplastic, esophageal nongoblet columnar epithelium, is,
essentially, unknown. In this study, 89 patients with metaplastic esophageal columnar …