[HTML][HTML] Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis
L Liu, RR Broaddus, JC Yao, SS Xie, JA White, TT Wu… - Modern Pathology, 2005 - Elsevier
Well-differentiated neuroendocrine tumors including pancreatic endocrine tumors and
carcinoid tumors are uncommon neoplasms that have site-specific differences in
clinicopathological features, clinical course and genetic alterations. The epigenetic
alterations in these tumors are not well characterized. We therefore compared methylation of
the RAS-association domain family 1, isoform A (RASSF1A), p14, p16 and O 6-methyl-
guanine methyltransferase genes in neuroendocrine tumors from 47 patients including 16 …
carcinoid tumors are uncommon neoplasms that have site-specific differences in
clinicopathological features, clinical course and genetic alterations. The epigenetic
alterations in these tumors are not well characterized. We therefore compared methylation of
the RAS-association domain family 1, isoform A (RASSF1A), p14, p16 and O 6-methyl-
guanine methyltransferase genes in neuroendocrine tumors from 47 patients including 16 …