In mammals, metabolic adaptations are required to cope with episodes of protein
deprivation and malnutrition. Consequently, mammals have to adjust physiological functions
involved in the adaptation to amino acid availability. Part of this regulation involves the
modulation of the expression of numerous genes. In particular, it has been shown that amino
acids by themselves can modify the expression of target genes. This review describes the
regulation of amino acids homeostasis and the their role as signal molecules. The recent …