Loss of matrix metalloproteinase 9 activity in Theileria annulata-attenuated cells is at the transcriptional level and is associated with differentially expressed AP-1 …
R Adamson, M Logan, J Kinnaird, G Langsley… - Molecular and …, 2000 - Elsevier
The schizont stage of the protozoan parasite Theileria annulata reversibly transforms bovine
monocytes into an immortalised and metastatic state. We have been studying T. annulata
induction of host matrix metalloproteinases (MMP) which are involved in parasite
dissemination and pathogenesis. We have observed that prolonged in vitro culture of T.
annulata-infected cell lines results in their attenuation and this process is associated with
alterations in both host and parasite gene expression. In particular, a loss in bovine MMP …
monocytes into an immortalised and metastatic state. We have been studying T. annulata
induction of host matrix metalloproteinases (MMP) which are involved in parasite
dissemination and pathogenesis. We have observed that prolonged in vitro culture of T.
annulata-infected cell lines results in their attenuation and this process is associated with
alterations in both host and parasite gene expression. In particular, a loss in bovine MMP …