[HTML][HTML] Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element-binding protein
M Ichiba, K Nakajima, Y Yamanaka, N Kiuchi… - Journal of Biological …, 1998 - ASBMB
STAT3 (signal transducer and activator of transcription 3) is a key transcription factor
mediating the signals for a variety of cytokines, including interleukin-6 (IL-6). The Stat3 gene
itself is activated by IL-6 signals. We show that the region of the signal-transducing subunit,
gp130, essential for STAT3 activation, is also required for activation of the Stat3 gene. To
elucidate the mechanisms activating the Stat3 gene, we identified an IL-6 response element
(IL-6RE) in the Stat3gene promoter containing both a low affinity STAT3-binding element …
mediating the signals for a variety of cytokines, including interleukin-6 (IL-6). The Stat3 gene
itself is activated by IL-6 signals. We show that the region of the signal-transducing subunit,
gp130, essential for STAT3 activation, is also required for activation of the Stat3 gene. To
elucidate the mechanisms activating the Stat3 gene, we identified an IL-6 response element
(IL-6RE) in the Stat3gene promoter containing both a low affinity STAT3-binding element …