Non-alcoholic steatohepatitis (NASH) is an increasing recognized condition that may
progress to end-stage liver disease. There are consistent evidences that mitochondrial
dysfunction plays a central role in NASH whatever its origin. Mitochondria are the key
controller of fatty acids removal and this is part of an intensive gene program that modifies
hepatocytes to counteract the excessive fat storage. Mitochondrial dysfunction participates at
different levels in NASH pathogenesis since it impairs fatty liver homeostasis and induces …