[HTML][HTML] Obligate role for ketone body oxidation in neonatal metabolic homeostasis
DG Cotter, DA d'Avignon, AE Wentz, ML Weber… - Journal of Biological …, 2011 - ASBMB
To compensate for the energetic deficit elicited by reduced carbohydrate intake, mammals
convert energy stored in ketone bodies to high energy phosphates. Ketone bodies provide
fuel particularly to brain, heart, and skeletal muscle in states that include starvation,
adherence to low carbohydrate diets, and the neonatal period. Here, we use novel Oxct1−/−
mice, which lack the ketolytic enzyme succinyl-CoA: 3-oxo-acid CoA-transferase (SCOT), to
demonstrate that ketone body oxidation is required for postnatal survival in mice. Although …
convert energy stored in ketone bodies to high energy phosphates. Ketone bodies provide
fuel particularly to brain, heart, and skeletal muscle in states that include starvation,
adherence to low carbohydrate diets, and the neonatal period. Here, we use novel Oxct1−/−
mice, which lack the ketolytic enzyme succinyl-CoA: 3-oxo-acid CoA-transferase (SCOT), to
demonstrate that ketone body oxidation is required for postnatal survival in mice. Although …