[HTML][HTML] Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells
M Wong, S Uddin, B Majchrzak, T Huynh… - Journal of Biological …, 2001 - ASBMB
The chemokine RANTES (regulated on activation normal T cell expressed and secreted)
and its cognate receptor CC chemokine receptor 5 (CCR5) have been implicated in
regulating immune cell function. Previously we reported that in T cells, RANTES activation of
CCR5 results in Stat1 and Stat3 phosphorylation-activation, leading to Stat1: 1 and Stat1: 3
dimers that exhibit DNA binding activity and the transcriptional induction of a Stat-inducible
gene, c-fos. Given that RANTES and CCR5 have been implicated in T cell activation, we …
and its cognate receptor CC chemokine receptor 5 (CCR5) have been implicated in
regulating immune cell function. Previously we reported that in T cells, RANTES activation of
CCR5 results in Stat1 and Stat3 phosphorylation-activation, leading to Stat1: 1 and Stat1: 3
dimers that exhibit DNA binding activity and the transcriptional induction of a Stat-inducible
gene, c-fos. Given that RANTES and CCR5 have been implicated in T cell activation, we …