Effect of Isoflurane and Other Potent Inhaled Anesthetics on Minimum Alveolar Concentration, Learning, and the Righting Reflex in Mice Engineered to Express α1γ …
JM Sonner, DF Werner, FP Elsen, Y Xing… - The Journal of the …, 2007 - pubs.asahq.org
Background Enhancement of the function of gamma-aminobutyric acid type A receptors
containing the alpha1 subunit may underlie a portion of inhaled anesthetic action. To test
this, the authors created gene knock-in mice harboring mutations that render the receptors
insensitive to isoflurane while preserving sensitivity to halothane. Methods The authors
recorded miniature inhibitory synaptic currents in hippocampal neurons from hippocampal
slices from knock-in and wild-type mice. They also determined the minimum alveolar …
containing the alpha1 subunit may underlie a portion of inhaled anesthetic action. To test
this, the authors created gene knock-in mice harboring mutations that render the receptors
insensitive to isoflurane while preserving sensitivity to halothane. Methods The authors
recorded miniature inhibitory synaptic currents in hippocampal neurons from hippocampal
slices from knock-in and wild-type mice. They also determined the minimum alveolar …