[HTML][HTML] Toll-like receptor 4 mediates induction of the Bcl10-NFκB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells
S Bhattacharyya, R Gill, ML Chen, F Zhang… - Journal of Biological …, 2008 - ASBMB
The sulfated polysaccharide carrageenan (CGN) induces activation of NFκB and interleukin
8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by
Bcl10 (B-cell CLL/lymphoma 10). In this report, we identify Toll-like receptor 4 (TLR4), a
member of the family of innate immune receptors, as the surface membrane receptor for
CGN in human colonic epithelial cells. Experiments with fluorescence-tagged CGN
demonstrated a marked reduction in binding of CGN to human intestinal epithelial cells and …
8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by
Bcl10 (B-cell CLL/lymphoma 10). In this report, we identify Toll-like receptor 4 (TLR4), a
member of the family of innate immune receptors, as the surface membrane receptor for
CGN in human colonic epithelial cells. Experiments with fluorescence-tagged CGN
demonstrated a marked reduction in binding of CGN to human intestinal epithelial cells and …