The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus
RA Brown, JH Gralewski… - Clinical Infectious …, 2009 - academic.oup.com
RA Brown, JH Gralewski, RR Razonable
Clinical Infectious Diseases, 2009•academic.oup.comAbstract Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the
presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-
mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This
immunologic impairment could serve as a biologic mechanism underlying the association
between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.
presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-
mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This
immunologic impairment could serve as a biologic mechanism underlying the association
between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.
Abstract
Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.
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