Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS
SM Richardson-Burns… - Archives of …, 2002 - jamanetwork.com
Context Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of
the central nervous system (CNS) caused by JC virus (JCV) that occurs in
immunocompromised patients. Demyelination of the CNS is a consequence of virus-induced
killing of oligodendrocytes, although the exact mechanism of cell death is unknown.
Objective To examine archival autopsy and surgical pathologic specimens from 8 patients
with PML, including 6 patients with human immunodeficiency virus (HIV)-associated PML …
the central nervous system (CNS) caused by JC virus (JCV) that occurs in
immunocompromised patients. Demyelination of the CNS is a consequence of virus-induced
killing of oligodendrocytes, although the exact mechanism of cell death is unknown.
Objective To examine archival autopsy and surgical pathologic specimens from 8 patients
with PML, including 6 patients with human immunodeficiency virus (HIV)-associated PML …