Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive multifocal leukoencephalopathy: a multicohort analysis
Aids, 2008•journals.lww.com
Objective: To establish the effectiveness of cidofovir for AIDS-related progressive multifocal
leukoencephalopathy (PML) in patients concomitantly receiving combination antiretroviral
therapy. Design: Analysis of raw data pooled from one prospective and five cohort studies.
Setting: Tertiary care centers for the treatment of HIV-associated complications. Patients:
Three hundred seventy HIV-infected PML patients diagnosed from 1996 treated with
combination antiretroviral therapy with or without cidofovir. All studies had already published …
leukoencephalopathy (PML) in patients concomitantly receiving combination antiretroviral
therapy. Design: Analysis of raw data pooled from one prospective and five cohort studies.
Setting: Tertiary care centers for the treatment of HIV-associated complications. Patients:
Three hundred seventy HIV-infected PML patients diagnosed from 1996 treated with
combination antiretroviral therapy with or without cidofovir. All studies had already published …
Abstract
Objective:
To establish the effectiveness of cidofovir for AIDS-related progressive multifocal leukoencephalopathy (PML) in patients concomitantly receiving combination antiretroviral therapy.
Design:
Analysis of raw data pooled from one prospective and five cohort studies.
Setting:
Tertiary care centers for the treatment of HIV-associated complications.
Patients:
Three hundred seventy HIV-infected PML patients diagnosed from 1996 treated with combination antiretroviral therapy with or without cidofovir. All studies had already published their results but for four of them, additional patients and follow-up data are included in this report. Follow-up was started from the date of first abnormal neuroimaging; those treated with cidofovir were entered at risk at the date of cidofovir initiation.
Lippincott Williams & Wilkins