PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

JC Lawrence, RT Abraham - Trends in biochemical sciences, 1997 - cell.com
JC Lawrence, RT Abraham
Trends in biochemical sciences, 1997cell.com
REVIEWS PHAS/4EoBPs as regu aters ef mRNA tra as atien and ee l proNeratien Page 1 TtBS
22 - SEPTEMBER 1997 REVIEWS • r PHAS/4EoBPs as regu aters ef mRNA tra as atien and
ee l proNeratien John CLawrence , Jr and Robert i. Abraham Insulin and growth factors elicit
rapid increases in protein synthesis by stimulating rnRNA translation. PHAS/4E-BPs, a recently
discovered family of elF4E-binding proteins, appear to play a key role in this process, as well
as in the control of cell proliferation. THE TNANSLAT[ION OF mRNA into protein is a comNex …
Abstract
Insulin and growth factors elicit rapid increases in protein synthesis by stimulating mRNA translation. PHAS/4E-BPs, a recently discovered family of elF4E-binding proteins, appear to play a key role in this process, as well as in the control of cell proliferation.
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