Significance of plasma transforming growth factor-β levels in radiotherapy for non–small-cell lung cancer
K De Jaeger, Y Seppenwoolde, HH Kampinga… - International Journal of …, 2004 - Elsevier
PURPOSE: In dose-escalation studies of radiotherapy (RT) for non–small-cell lung cancer
(NSCLC), radiation pneumonitis (RP) is the most important dose-limiting complication.
Transforming growth factor-β1 (TGF-β1) has been reported to be associated with the
incidence of RP. It has been proposed that serial measurements of plasma TGF-β1 can be
valuable to estimate the risk of RP and to decide whether additional dose-escalation can be
safely applied. The aim of this study was to evaluate prospectively the time course of TGF-β1 …
(NSCLC), radiation pneumonitis (RP) is the most important dose-limiting complication.
Transforming growth factor-β1 (TGF-β1) has been reported to be associated with the
incidence of RP. It has been proposed that serial measurements of plasma TGF-β1 can be
valuable to estimate the risk of RP and to decide whether additional dose-escalation can be
safely applied. The aim of this study was to evaluate prospectively the time course of TGF-β1 …