Elevated plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 in patients with disseminated malignant melanoma
K Krasagakis, D Thölke, B Farthmann, J Eberle… - British journal of …, 1998 - nature.com
K Krasagakis, D Thölke, B Farthmann, J Eberle, U Mansmann, CE Orfanos
British journal of cancer, 1998•nature.comOverexpression of transforming growth factor-beta isoforms (TGF-beta1,-beta2,-beta3) has
been previously reported in human melanoma cell lines and tumours. The aim of the present
study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients.
Significantly elevated levels of TGF-beta1 (4.2 x the controls, P= 0.0094) and of TGF-beta2
(1.5 x the controls, P= 0.012) but not of TGF-beta3 were measured in patients with
disseminated but not locoregional melanoma. These results indicate systemic circulation of …
been previously reported in human melanoma cell lines and tumours. The aim of the present
study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients.
Significantly elevated levels of TGF-beta1 (4.2 x the controls, P= 0.0094) and of TGF-beta2
(1.5 x the controls, P= 0.012) but not of TGF-beta3 were measured in patients with
disseminated but not locoregional melanoma. These results indicate systemic circulation of …
Abstract
Overexpression of transforming growth factor-beta isoforms (TGF-beta1,-beta2,-beta3) has been previously reported in human melanoma cell lines and tumours. The aim of the present study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients. Significantly elevated levels of TGF-beta1 (4.2 x the controls, P= 0.0094) and of TGF-beta2 (1.5 x the controls, P= 0.012) but not of TGF-beta3 were measured in patients with disseminated but not locoregional melanoma. These results indicate systemic circulation of potentially immunosuppressive peptides of the TGF-beta family in end-stage melanoma patients.
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