Fibrin glue as a drug delivery system
PP Spicer, AG Mikos - Journal of controlled release, 2010 - Elsevier
PP Spicer, AG Mikos
Journal of controlled release, 2010•ElsevierFibrin glue has been used surgically for decades for hemostasis as well as a sealant. It has
also been researched as both a gel for cell delivery and a vehicle for drug delivery. The drug
delivery applications for fibrin glue span tissue engineering to chemotherapy and involve
several mechanisms for drug matrix interactions and control of release kinetics. Additionally,
drugs or factors can be loaded in the gel via impregnation and tethering to the gel through
covalent linkages or affinity-based systems. This review highlights recent research of fibrin …
also been researched as both a gel for cell delivery and a vehicle for drug delivery. The drug
delivery applications for fibrin glue span tissue engineering to chemotherapy and involve
several mechanisms for drug matrix interactions and control of release kinetics. Additionally,
drugs or factors can be loaded in the gel via impregnation and tethering to the gel through
covalent linkages or affinity-based systems. This review highlights recent research of fibrin …
Fibrin glue has been used surgically for decades for hemostasis as well as a sealant. It has also been researched as both a gel for cell delivery and a vehicle for drug delivery. The drug delivery applications for fibrin glue span tissue engineering to chemotherapy and involve several mechanisms for drug matrix interactions and control of release kinetics. Additionally, drugs or factors can be loaded in the gel via impregnation and tethering to the gel through covalent linkages or affinity-based systems. This review highlights recent research of fibrin glue as a drug delivery vehicle.
Elsevier