Granulocyte–macrophage colony-stimulating factor: not just another haematopoietic growth factor
A Francisco-Cruz, M Aguilar-Santelises… - Medical oncology, 2014 - Springer
A Francisco-Cruz, M Aguilar-Santelises, O Ramos-Espinosa, D Mata-Espinosa…
Medical oncology, 2014•SpringerGranulocyte–macrophage colony-stimulating factor (GM-CSF) is often used to treat
leucopenia. Other haematopoietins may increase the number of circulating leucocytes with
higher efficiency, but GM-CSF has additional effects that may be far more relevant than its
haematopoietic activity. GM-CSF induces differentiation, proliferation and activation of
macrophages and dendritic cells which are necessary for the subsequent T helper cell type
1 and cytotoxic T lymphocyte activation. GM-CSF haematopoietic and non-haematopoietic …
leucopenia. Other haematopoietins may increase the number of circulating leucocytes with
higher efficiency, but GM-CSF has additional effects that may be far more relevant than its
haematopoietic activity. GM-CSF induces differentiation, proliferation and activation of
macrophages and dendritic cells which are necessary for the subsequent T helper cell type
1 and cytotoxic T lymphocyte activation. GM-CSF haematopoietic and non-haematopoietic …
Abstract
Granulocyte–macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. Other haematopoietins may increase the number of circulating leucocytes with higher efficiency, but GM-CSF has additional effects that may be far more relevant than its haematopoietic activity. GM-CSF induces differentiation, proliferation and activation of macrophages and dendritic cells which are necessary for the subsequent T helper cell type 1 and cytotoxic T lymphocyte activation. GM-CSF haematopoietic and non-haematopoietic functions have pro-inflammatory and immune regulatory potential to treat a variety of autoimmune diseases and tumours. On the other hand, GM-CSF deficiency leads to various immune dysfunctions and the current utilization of GM-CSF as haematopoietic factor might be an accurate but very incomplete indication for a cytokine with vast clinical potential.
Springer
