[HTML][HTML] Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity
Integrin α 4 β 7 controls lymphocyte trafficking into the gut and has essential roles in
inflammatory bowel disease (IBD). The α 4 β 7-blocking antibody vedolizumab is approved
for IBD treatment; however, high dose of vedolizumab aggravates colitis in a small
percentage of patients. Herein, we show that integrin β 7 deficiency results in colonic
regulatory T (Treg) cell depletion and exacerbates dextran sulfate sodium (DSS) colitis by
evoking aberrant innate immunity. In DSS-treated β 7-deficient mice, the loss of colonic Treg …
inflammatory bowel disease (IBD). The α 4 β 7-blocking antibody vedolizumab is approved
for IBD treatment; however, high dose of vedolizumab aggravates colitis in a small
percentage of patients. Herein, we show that integrin β 7 deficiency results in colonic
regulatory T (Treg) cell depletion and exacerbates dextran sulfate sodium (DSS) colitis by
evoking aberrant innate immunity. In DSS-treated β 7-deficient mice, the loss of colonic Treg …
