Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of
oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review,
we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids
with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and
phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid
species. For each class of oxPL we will review the chemical mechanisms of their formation …