The pancreas secretes digestive proenzymes typically in their monomeric form. A notable
exception is the ternary complex formed by proproteinase E, chymotrypsinogen C, and
procarboxypeptidase A (proCPA) in cattle and other ruminants. In the human and pig
pancreas binary complexes of proCPA with proelastases were found. To characterize
complex formation among human pancreatic protease zymogens in a systematic manner,
we performed binding experiments using recombinant proelastases CELA2A, CELA3A, and …