[HTML][HTML] Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesis
UK Bhanot, P Möller - Laboratory investigation, 2009 - Elsevier
The pathobiology of chronic pancreatitis (CP) remains enigmatic despite remarkable
progress made recently in uncovering key mechanisms involved in the initiation and
progression of the disease. CP is increasingly thought of as a multifactorial disorder.
Apoptosis plays a role in parenchymal destruction, the pathological hallmark of CP. The
apoptotic mechanisms preferentially target the exocrine compartment, leaving endocrine
islets relatively intact for a prolonged period. Exocrine cells shed their 'immunoprivileged' …
progress made recently in uncovering key mechanisms involved in the initiation and
progression of the disease. CP is increasingly thought of as a multifactorial disorder.
Apoptosis plays a role in parenchymal destruction, the pathological hallmark of CP. The
apoptotic mechanisms preferentially target the exocrine compartment, leaving endocrine
islets relatively intact for a prolonged period. Exocrine cells shed their 'immunoprivileged' …
