Control of global histone acetylation status is largely governed by the opposing enzymatic
activities of histone acetyltransferases and deacetylases (HDACs). HDACs were originally
identified as modulators of nuclear histone acetylation status and have been linked to
chromosomal condensation and subsequent gene repression. Accumulating evidence
highlights HDAC modification of non-histone targets. Mitochondria were first characterized
as intracellular organelles responsible for energy production through the coupling of …