A protein known to regulate both lipid metabolism and vesicular transport is the
phosphatidylcholine/phosphatidylinositol transfer protein Sec14 of Saccharomyces
cerevisiae. Sec14 is thought to globally affect secretion from the trans-Golgi. The results from
a synthetic genetic array screen for genes whose inactivation impaired growth of cells with a
temperature-sensitive SEC14 allele implied Sec14 regulates transport into and out of the
Golgi. This prompted us to examine the role of Sec14 in various vesicular transport …