Larazotide acetate promotes tight junction assembly in epithelial cells
S Gopalakrishnan, A Tripathi, AP Tamiz, SS Alkan… - Peptides, 2012 - Elsevier
Tight junctions (TJ) control paracellular permeability and apical-basolateral polarity of
epithelial cells. Dysregulated permeability is associated with pathological conditions, such
as celiac disease and inflammatory bowel disease. TJ formation is dependent on E-cadherin-
mediated cell-cell adhesion and actin rearrangement, and is regulated by the Rho family
GTPase and aPKC signaling pathways. Larazotide acetate, an 8-mer peptide and TJ
modulator, inhibits TJ disassembly and dysfunction caused by endogenous and exogenous …
epithelial cells. Dysregulated permeability is associated with pathological conditions, such
as celiac disease and inflammatory bowel disease. TJ formation is dependent on E-cadherin-
mediated cell-cell adhesion and actin rearrangement, and is regulated by the Rho family
GTPase and aPKC signaling pathways. Larazotide acetate, an 8-mer peptide and TJ
modulator, inhibits TJ disassembly and dysfunction caused by endogenous and exogenous …