[HTML][HTML] Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis
Expression of claudin-2, a tight junction protein, is highly upregulated during inflammatory
bowel disease (IBD) and, due to its association with epithelial permeability, has been
postulated to promote inflammation. Notably, claudin-2 has also been implicated in the
regulation of intestinal epithelial proliferation. However, precise role of claudin-2 in
regulating colonic homeostasis remains unclear. Here, we demonstrate, using Villin-Claudin-
2 transgenic mice, that increased colonic claudin-2 expression augments mucosal …
bowel disease (IBD) and, due to its association with epithelial permeability, has been
postulated to promote inflammation. Notably, claudin-2 has also been implicated in the
regulation of intestinal epithelial proliferation. However, precise role of claudin-2 in
regulating colonic homeostasis remains unclear. Here, we demonstrate, using Villin-Claudin-
2 transgenic mice, that increased colonic claudin-2 expression augments mucosal …