[HTML][HTML] The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration
The integrin-binding secreted protein developmental endothelial locus-1 (DEL-1) is involved
in the regulation of both the initiation and resolution of inflammation in different diseases,
including periodontitis, an oral disorder characterized by inflammatory bone loss. Here,
using a mouse model of bone regeneration and in vitro cell-based mechanistic studies, we
investigated whether and how DEL-1 can promote alveolar bone regeneration during
resolution of experimental periodontitis. Compared with WT mice, mice lacking DEL-1 or …
in the regulation of both the initiation and resolution of inflammation in different diseases,
including periodontitis, an oral disorder characterized by inflammatory bone loss. Here,
using a mouse model of bone regeneration and in vitro cell-based mechanistic studies, we
investigated whether and how DEL-1 can promote alveolar bone regeneration during
resolution of experimental periodontitis. Compared with WT mice, mice lacking DEL-1 or …