Membrane Proteinase 3 Expression in Patients with Wegener's Granulomatosis and in Human Hematopoietic Stem Cell–Derived Neutrophils
A large membrane proteinase 3 (mPR3)-positive neutrophil subset (mPR3 high) is a risk for
Wegener's granulomatosis (WG). The relationship between mPR3 expression and clinical
manifestations was investigated in 81 WG patients and mPR3 expression was studied in
CD34+ stem cell–derived human neutrophils. The mPR3 high neutrophil percentage
correlated with renal function, anemia, and albumin at the time of presentation. The mPR3
high neutrophil percentage and renal failure severity correlated directly after 5 yr. For …
Wegener's granulomatosis (WG). The relationship between mPR3 expression and clinical
manifestations was investigated in 81 WG patients and mPR3 expression was studied in
CD34+ stem cell–derived human neutrophils. The mPR3 high neutrophil percentage
correlated with renal function, anemia, and albumin at the time of presentation. The mPR3
high neutrophil percentage and renal failure severity correlated directly after 5 yr. For …
