[HTML][HTML] Human hepatocyte nuclear factor 4-α encodes isoforms with distinct transcriptional functions
É Lambert, JP Babeu, J Simoneau, J Raisch… - Molecular & Cellular …, 2020 - ASBMB
HNF4α is a nuclear receptor produced as 12 isoforms from two promoters by alternative
splicing. To characterize the transcriptional capacities of all 12 HNF4α isoforms, stable lines
expressing each isoform were generated. The entire transcriptome associated with each
isoform was analyzed as well as their respective interacting proteome. Major differences
were noted in the transcriptional function of these isoforms. The α1 and α2 isoforms were the
strongest regulators of gene expression whereas the α3 isoform exhibited significantly …
splicing. To characterize the transcriptional capacities of all 12 HNF4α isoforms, stable lines
expressing each isoform were generated. The entire transcriptome associated with each
isoform was analyzed as well as their respective interacting proteome. Major differences
were noted in the transcriptional function of these isoforms. The α1 and α2 isoforms were the
strongest regulators of gene expression whereas the α3 isoform exhibited significantly …